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KMID : 0351619670080020243
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Kyungpook Medical Journal
1967 Volume.8 No. 2 p.243 ~ p.252
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Erythropoietin Studies in Various Hematologic Disorders
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Abstract
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Using incorporation of Fe s9 into erythrocytes of starved rats, erythropoietin activity vas assayed in plasma of 10 normal male subjects serving as control and 115 patients with a variety of hematologic disorders.
Highest activity was found in patients with aplastic anemia. Moderately high activity was observed in subjects with acute posthemorrhagic anemia, acute leukemia, splenic anemia and iron deficiency anemia. Assays in patients with hemolytic anemia and chronic myelogenous leukemia revealed slightly elevated levels.
These studies demonstrated that as the severity of anemia increased, the activity of erythropoietin in plasma increased proportionately, and also as hemoglobin values decreased below 6 or 7 gm % patients with aplastic anemia, iron deficiency anemia as well as splenic anemia showed a~1 abrupt and marked rise in erythropoietin activity.
A log close response relationship was noted between erythropoietin activity and marrow erythroid count of the rats infused with the plasma of the patients with iron deficiency anemia and aplastic anemia.
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